Comparison of the Host Responses to Wild-Type and<i>cpsB</i>Mutant<i>Klebsiella pneumoniae</i>Infections

Abstract

Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.