Severe eosinophilic fasciitis: comparison of treatment with<scp>d</scp>-penicillamine plus corticosteroids vs. corticosteroids alone

Abstract

Treatment with CS alone failed to induce clinical improvement in the majority of the severe eosinophilic fasciitis patients. By contrast, d-Pen plus CS resulted in significantly greater clinical improvement. These results suggest that initial treatment of severe eosinophilic fasciitis with CS alone is not sufficient for optimal therapeutic response and that addition of an antifibrotic agent results in an improved outcome.