Estrogen-related receptor γ controls hepatic CB ₁ receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol

Abstract

ERRγ, as a previously unrecognised transcriptional regulator of hepatic CB1 receptor, controls alcohol-induced oxidative stress and liver injury through CYP2E1 induction, and its inverse agonist could ameliorate oxidative liver injury due to chronic alcohol exposure.