Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella Pneumoniae in mice

Abstract

Exposure to inhaled FP impairs pulmonary clearance of K. pneumoniae in mice, an effect associated with greater systemic bacteremia and death. Decreased AM cytokine and nitric oxide expression parallel the failure to control infection. These results support the study of ICS effects on human pulmonary host defenses.