Bacterial Endotoxin: Effects on Erythropoiesis

Abstract

Abstract Mice injected with a single, large dose of a bacterial endotoxin displayed a significant shift in erythropoiesis from the bone marrow to the spleen. Splenic granulocytopoiesis also occurred. This finding may have some bearing on the observation that endotoxin pretreated mice make a better recovery following x-irradiation than do their controls.