A Highly Effective Phosphoramidite Ligand for Asymmetric Allylic Substitution

Abstract

Very high enantioselectivity has been achieved both in the copper-catalyzed alkylation of allylic substrates by Grignard and organozinc reagents and in the iridium-catalyzed amination of cinnamyl carbonate by employing a very efficient phosphoramidite ligand (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z53744_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.