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Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant β-Lactamase from<i>Klebsiella pneumoniae</i>

Véronique Dubois, Laurent Poirel, François Demarthe, Corinne Arpin, Laure Coulange, Luciene Andrade da Rocha Minarini, M.C. Bezian, Patrice Nordmann, Claudine Quentin

Antimicrobial Agents and Chemotherapy · 2008 · 30 citations · 18 references

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Abstract

A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.

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