THE KINETICS OF TOLERANCE INDUCTION BY NONDEPLETING ANTI-CD4 MONOCLONAL ANTIBODY (RIB 5/2) PLUS INTRAVENOUS DONOR ALLOANTIGEN ADMINISTRATION 1,2

Abstract

A single dose of the nondepleting anti-CD4 monoclonal antibody, RIB 5/2, plus i.v. alloantigen is a potent inducer of tolerance to heart and kidney, but not skin, allografts. The RIB 5/2-induced donor unresponsiveness to a delayed kidney or cardiac allograft is time dependent but can be prolonged if specific alloantigen is present. Suppression of cell-mediated allo-immune responsiveness correlates with allograft acceptance.