Pure and Applied Chemistry · 2002 · 18 citations · 0 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryNeuropharmacologySynthetic Medicinal ChemistryNeurodegenerative Disease PharmacologyNeurodegenerative Disease PharmacotherapyMedicinal Chemistry ApplicationsMedicinal HeterocyclesParkinson's Disease PharmacotherapyParkinson’s Disease PharmacotherapyParkinson’s Disease Treatment
Abstract A new synthesis of sumanirole that is being developed to treat Parkinson's disease is described. The basic skeleton is constructed from 8-hydroxyquinoline and elaborated to the key tricylic intermediate 14. Further elaboration affords a 1,2-amino alcohol, which is converted to an aziridine by a new process. Finally, dissolving metal reduction to open the aziridine and protecting group removal affords sumanirole.