Augmented retinal endothelin-1, endothelin-3, endothelinA and endothelinB gene expression in chronic diabetes

Abstract

These findings indicate that retinal ET-1, ET-3, ET(A) and ET(B) mRNA expression in increased in the chronically diabetic BB/W rat. Augmented gene expression of ETs and their receptors potentially may be of importance in the pathogenesis of retinal microangiopathy in diabetes.