Phosphodiester bond cleavage mediated by a cyclic β-sheet peptide-based dinuclear zinc(ii) complex

Abstract

A dinuclear Zn(II) complex of N2δ,N2δ,N 2′δ,N2′δ-tetra kis(2-pyridylmethyl) derivative of cyclic peptide gramicidin S markedly accelerated the cleavage of the phosphodiester linkage of the RNA model substrate 2-hydroxypropyl p-nitrophenyl phosphate.