ALLOXAN DIABETES IN THE HAMSTER: DOSAGE AND BLOOD SUGAR CURVES1

Abstract

INTRODUCTION DESPITE the extensive literature, only two articles, Harris, Anderson and Chen (1946) and Phatak, Lai and Everett (1950) deal with alloxan and the hamster. In neither was the method of injection, the exact diabetic dose, the form of the blood sugar curve, the duration of the diabetic symptoms or the survival time made clear. Since all of this information was pertinent to proposed studies employing the hamster cheek pouch in diabetic animals, the work reported here was undertaken.