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EFFECT OF PYRIDOXINE ON HUMAN HYPOPHYSEAL TROPHIC HORMONE RELEASE: A POSSIBLE STIMULATION OF HYPOTHALAMIC DOPAMINERGIC PATHWAY.
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1976
Year
Human GrowthSocial SciencesReproductive EndocrinologyPituitary GlandNeuroendocrine MechanismHypothalamic PeptidePlasma Prolactin PrlHospitalized Healthy SubjectsGrowth HormoneEndocrine MechanismNervous SystemEndocrinologyPharmacologyDopamineNeurophysiologyPhysiologyNeuroscienceGh SecretionMedicine
A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine.