TBAF-Catalyzed Synthesis of 5-Substituted 1<i>H</i>-Tetrazoles under Solventless Conditions

Abstract

Tetrabutylammonium fluoride (TBAF) is an efficient catalyst in the [3 + 2] cycloaddition reaction of organic nitriles 1 with trimethylsilyl azide (TMSN(3)) in solventless conditions. The corresponding 5-substituted 1H-tetrazoles 2 were obtained under mild conditions and in 80-97% yields.