The Use of Silver Solid Amalgam Working Electrode for Determination of Nitrophenols by HPLC with Electrochemical Detection

Abstract

Abstract The use of a silver solid amalgam working electrode for HPLC with electrochemical detection has been investigated. The thin‐layer and wall‐jet detectors based on this electrode were constructed and applied for the determination of a mixture of nitrophenols. The optimal separation and detection conditions for the determination of 2‐nitrophenol, 4‐nitrophenol, 2,4‐dinitrophenol and 2‐methoxy‐5‐nitrophenol in mixture were found using RP‐HPLC at Nova‐Pack C18 column and amperometric detection with the above mentioned detectors. It has been proved that the silver solid amalgam electrode is a suitable working electrode for HPLC‐ED and provides sufficient sensitivity for determination of tested nitrophenols.