The transcriptomic response of <i>Acinetobacter baumannii</i> to colistin and doripenem alone and in combination in an <i>in vitro</i> pharmacokinetics/pharmacodynamics model

Abstract

These data suggest that colistin causes gross damage to the outer membrane, facilitates lipid exchange between the inner and outer membrane and alters the normal asymmetric outer membrane composition. The transcriptional response to colistin was highly similar to that observed for an LPS-deficient strain, indicating that many of the observed changes are responses to outer membrane instability resulting from LPS loss.