Inhibition of Protein Kinase CK2 Closes the CFTR Cl<sup>-</sup> Channel, but has no Effect on the Cystic Fibrosis Mutant ΔF508-CFTR

Abstract

CK2 controls wtCFTR, but not DeltaF508-CFTR. Others find that peptides from the F508 region of NBD1 allosterically control CK2, acting through F508. Hence, disruption of CK2-CFTR interaction by DeltaF508-CFTR might disrupt multiple, membrane-associated, CK2-dependent pathways, creating a new molecular disease paradigm for deleted F508 in CFTR.