A New Scaffold for the Stereoselective Synthesis of α-<i>O</i>-Linked Glycopeptide Mimetics

Abstract

alpha-O-Linked glycohomoglutamates are obtained as diastereomerically pure compounds by chemo-, regio-, and stereoselective cycloadditions between glycals and aspartic acid derivatives. The latter constitute orthogonally functionalized scaffolds for glycopeptide mimetics.