Generation of HNO and HSNO from Nitrite by Heme‐Iron‐Catalyzed Metabolism with H₂S

Abstract

Taking NO for an answer: A mechanistic study has shown that a heme-iron-catalyzed pathway (see scheme) could lead to the nitrite-/sulfide-induced formation of NO and HNO within mitochondria, and suggests that H2S may be the elusive thiol responsible for the reduction of nitrite. This study offers an answer to the decades-old question on the role of nitrite in the treatment of H2S poisoning. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.