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SOME RECENT STUDIES BEARING ON THE ONE GENE-ONE ENZYME HYPOTHESIS
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1951
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E. ColiGeneticsMolecular BiologyMolecular GeneticsGenomicsBiosynthesisGene ActionSingle EnzymeStructure-function Enzyme KineticsBiochemistryMolecular MicrobiologyGene ExpressionFunctional GenomicsProtein BiosynthesisBiologyCellular EnzymologyNatural SciencesGenetic EngineeringEnzyme SpecificityMicrobiologySymbiosisMedicine
The assumption that a given gene is involved, in a primary way, in the production of but a single enzyme has been implicit in most speculations on the nature of gene action since Cuénot's time. As a result of the investigations of the last ten years stemming from the discovery of nutritional mutants in Neurospora by Beadle and Tatum (1941), one is now in a position to scrutinize this supposition more closely than was previously possible. Specifically, we are in a better position to trace the consequences of the hypothesis and of its various alternatives, and to appraise the evidence which may have a bearing on it. In this paper we propose to examine some of the evidence, deriving from studies on Neurospora, and E. coli, which relates to this problem.