Phase I, double-blind, randomized, placebo-controlled, dose-escalation study of NI-0401 (a fully human anti-CD3 monoclonal antibody) in patients with moderate to severe active Crohnʼs disease† - Concepedia

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Phase I, double-blind, randomized, placebo-controlled, dose-escalation study of NI-0401 (a fully human anti-CD3 monoclonal antibody) in patients with moderate to severe active Crohnʼs disease†

DOI Full Paper Access

45

Citations

14

References

2010

Year

C. Janneke van der Woude, Pieter Stokkers, Ad A. van Bodegraven, Gert Van Assche, Zbigniew Hebzda, Leszek Paradowski, Geert D’Haens, Subrata Ghosh, Brian G. Feagan, Paul Rutgeerts,

Inflammatory Bowel Diseases

Abstract

NI-0401 was tolerated at doses ≤1 mg with manageable side effects. NI-0401 induced a dose-dependent modulation of the TCR-CD3 complex. No significant improvement of CDAI was observed but 1 mg NI-0401 demonstrated an improvement in CDEIS.

References

	Year	Citations

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