Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy

Abstract

Elevated levels of serum PICP indicated increased myocardial collagen synthesis in sarcomere-mutation carriers without overt disease. This profibrotic state preceded the development of left ventricular hypertrophy or fibrosis visible on MRI. (Funded by the National Institutes of Health and others.)