Radical‐Mediated γ‐Functionalizations of α,β‐Unsaturated Carboxylic Amides

Abstract

Highly successful tin-free, radical-mediated alkylations of α,β-unsaturated carboxylic amides have been carried out. Alkyl iodides and bromides bearing α-electron-withdrawing groups undergo selective γ-additions to diene O,N-acetals (see scheme). This approach to γ-functionalization was further extended to the use of hetero groups, such as phenylsulfanyl and phenylsulfonyl species. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460820_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.