Expanded Radialenes: Modular Synthesis and Characterization of Cross-Conjugated Enyne Macrocycles

Abstract

Stepwise palladium-catalyzed cross-coupling between terminal alkynes and vinyl triflates afforded the first cross-conjugated enyne macrocycles constructed of 3-alkylidene-1-propynyl [-C≡C-C(=CR₂)-] building blocks, namely, the expanded radialene 1 and the hybrid radialene 2.