Azithromycin and Loperamide Are Comparable to Levofloxacin and Loperamide for the Treatment of Traveler's Diarrhea in United States Military Personnel in Turkey

Abstract

Single-dose treatment with azithromycin (1000 mg) and loperamide is as effective as single-dose treatment with levofloxacin (500 mg) and loperamide for noninflammatory diarrhea. Although nausea after dosing is uncommon, it is more frequently associated with azithromycin than with levofloxacin. Future studies should focus on determining whether lower doses of azithromycin would decrease the frequency of nausea and decrease treatment costs without affecting efficacy.