Experimental production of carcinoma in rhesus monkeys.

Abstract

Summary Repeated application of a high-boiling catalytically cracked oil elicited papillomas on the skin of each of six rhesus monkeys. Continued application of this oil was followed by malignant change in papillomas on three of these monkeys. The response of the rhesus monkeys thus corresponded to that of mice and rabbits, both of which species developed papillomas and cancers after being painted with this oil, whereas rats and guinea pigs did not.