The Influence of Study Design on the Results of Pharmacoepidemiologic Studies of Diabetes Risk With Antipsychotic Therapy

Abstract

In database studies estimated risks of antipsychotic-related diabetes are affected by study design. With a more rigorous design, the risk associated with quetiapine and risperidone was not significantly different from that in untreated patients. These findings may explain inconsistent findings in pharmacoepidemiologic database studies.