Lara D. Veeken · 1986 · 19 citations · 0 references
MedicinePharmacologyPharmacotherapyClinical PharmacologyPharmacodynamicsRheumatologyAdverse Drug Reaction MonitoringAnti-inflammatory PharmacologyMedication Side Effect ManagementMedication UseRheumatoid ArthritisHepatic Function TestsInterpretation Of Liver Function TestsRheumatoid Arthritis PharmacotherapyRheumatoid Arthritis TherapySingle-blind Trials
Twenty-three patients with rheumatoid arthritis (RA) entered a single-blind cross-over study of sulphamethoxazole 2 g daily compared to placebo. Sulphamethoxazole was administered for 3 months during the 6-month study. Sulphamethoxazole exhibited properties commensurate with a second-line effect with a significant acute-phase reactant response and a parallel change in the clinical state. Adverse effects were common and resulted in nine drug-related withdrawals, mainly due to nausea and vomiting. There were also reversible abnormalities in liver function tests on the active drug. The role of sulphonamides in treatment of RA requires further exploration.