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Asymmetric Synthesis with <i>N</i>‐Heterocyclic Carbenes. Application to the Copper‐Catalyzed Conjugate Addition
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Citations
31
References
2003
Year
Chemical EngineeringEngineeringHeterocyclicVarious Michael AcceptorsGood LigandsAsymmetric SynthesisOrganic ChemistryCopper‐catalyzed Conjugate AdditionOrganometallic CatalysisCatalysisChemistryHeterocycle ChemistryAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringDialkylzinc Reagents
Abstract Chiral N ‐heterocyclic carbenes are good ligands for the copper‐catalyzed conjugate addition of dialkylzinc reagents to various Michael acceptors. With as little as 4% of chiral ligand, the enantioselectivity may reach 93% on cycloheptenone.
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