The Association Between Elevated EphB4 Expression, Smoking Status, and Advanced-Stage Disease in Patients With Head and Neck Squamous Cell Carcinoma

Abstract

Overexpression of EphB4 is associated with advanced stages of HNSCC as well as with patients who smoke. These data are the first to demonstrate the association of EphB4 with advanced stages of disease and smoking in HNSCC and hence provide a strong rationale for targeting EphB4 for HNSCC therapies.