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Impairment of endothelium-dependent relaxation of superior mesenteric artery in genetically diabetic WBN/Kob rats
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1993
Year
Cardiovascular FunctionOxidative StressInflammationWistar RatsNeurologyMicrovascular DysfunctionSuperior Mesenteric ArteryAtherosclerosisMechanobiologyVascular AdaptationEndothelium-dependent RelaxationVascular BiologyWbn/kob RatsCerebral Blood FlowDiabetic Wbn/kob RatsPharmacologyDiabetesPhysiologyEndothelial DysfunctionMedicine
The endothelium-dependent relaxation of superior mesenteric arteries of Wistar and genetically diabetic WBN/Kob rats was compared. Endothelium-dependent relaxation induced by acetylcholine (ACh) and A23187 was depressed in WBN/Kob rats. Relaxation induced by sodium nitroprusside, an endothelium-independent agent, in strips from WBN/Kob rats was similar to that in strips from Wistar rats. Indomethacin (5 x 10(-6) M) enhanced the relaxation responses to ACh in strips from both WBN/Kob and Wistar rats; however, endothelium-dependent relaxation induced by ACh remained attenuated in WBN/Kob rats. These results show that endothelium-dependent relaxation is impaired not only in thoracic aorta but also in superior mesenteric arteries in genetically diabetic rats.