Analogues of parthenin and their antibacterial activity

Abstract

Regio-and stereoselective chemical modifications of parthenin, a naturally occurring pseudoguaianolide, afforded its various natural and unnatural analogues whose antibacterial activity was studied.Parthenin itself and some of the analogues showed significant activity and with only one exception all of the active compounds were found to contain an intact αmethylene-γ-butyrolactone moiety.