Concepedia

Notch Pathway Inhibition Significantly Reduces Rhabdomyosarcoma Invasiveness and Mobility <i>In Vitro</i>

Josep Roma, A M Masia, Jaume Reventós, Joan Sánchez-de-Toledo, Soledad Gallego

Clinical Cancer Research · 2010 · 52 citations · 23 references

DOI

Abstract

Pharmacological or genetic blockage of the pathway significantly reduced invasiveness of RMS cell lines, thereby suggesting a possible role of the Notch pathway in the regulation of the metastatic process in RMS.

References

23

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

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Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

Freddy Radtke, Anne E. Wilson, Gerlinde Stark et al. · Immunity · 1999 · 1.4K citations · Full text

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The Regulation of Notch Signaling Controls Satellite Cell Activation and Cell Fate Determination in Postnatal Myogenesis

Irina M. Conboy, Thomas A. Rando · Developmental Cell · 2002 · 865 citations · Full text

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Notch Pathway Inhibition Depletes Stem-like Cells and Blocks Engraftment in Embryonal Brain Tumors

Xing Fan, William Matsui, Leila Khaki et al. · Cancer Research · 2006 · 614 citations

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.

Richard J. Davis, Celina M. D’Cruz, Mark A. Lovell et al. · PubMed · 1994 · 599 citations

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