An Expeditious Route to Eight‐Membered Heterocycles By Nickel‐Catalyzed Cycloaddition: Low‐Temperature CC Bond Cleavage

Abstract

A cool break: 3-Azetidinone and a variety of diynes undergo a cycloaddition reaction catalyzed by Ni/IPr to give dihydroazocine compounds (see scheme; IPr=1,3-bis(2,6-diisopropylphenyl)imidazolidene). The reaction involves a challenging C(sp)2-C(sp)3 bond cleavage step, yet, surprisingly, proceeds at low temperature.