Enantioselective Synthesis of the 5–6–7 Carbocyclic Core of the Gagunin Diterpenoids

Abstract

A catalytic enantioselective double allylic alkylation reaction has been employed in the synthesis of the core of the gagunin diterpenoids. Enantioenriched material was advanced in 11 steps to afford the core of the highly oxygenated target, which includes two all-carbon quaternary stereocenters.