Assessment of Interobserver Reproducibility in Quantitative ¹⁸F-FDG PET and CT Measurements of Tumor Response to Therapy

Abstract

The interobserver reproducibility of SUV(bw) max for both untreated and treated tumors and percentage change in SUV(bw) max are substantially higher than measurements of CT size and percentage change in CT size. Measurements of tumor metabolism by PET should be included in trials to assess response to therapy. Although PET reproducibility was high, the variability observed in analyses of identical image sets by 4 readers indicates that automated analytic tools to assess response might be helpful to further enhance reproducibility.