Concepedia

A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines

Ronald Grigg, Elghareeb E. Elboray, Sunisa Akkarasamiyo, Nutthawat Chuanopparat, H. Ali Döndaş, Hussien H. Abbas‐Temirek, Colin W. G. Fishwick, Moustafa F. Aly, Boonsong Kongkathip, Ngampong Kongkathip

Chemical Communications · 2015 · 16 citations · 35 references

DOI

Concepts

Abstract

Palladium catalysed three component cascade process, involving coupling of 2-iodobenzoates, -benzaldehydes, or acetophenones with substituted allenes and ammonium tartrate as an ammonium surrogate, provides a novel and facile route to substituted functionalised isoquinolinones and isoquinolines in good yields.

References

35

Rhodium(III)-Catalyzed Isoquinolone Synthesis: The N−O Bond as a Handle for C−N Bond Formation and Catalyst Turnover

Nicolas Guimond, Christina Gouliaras, Keith Fagnou · Journal of the American Chemical Society · 2010 · 769 citations

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Mild Rhodium(III)‐Catalyzed CH Activation and Intermolecular Annulation with Allenes

Honggen Wang, Frank Glorius · Angewandte Chemie International Edition · 2012 · 367 citations

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Ruthenium-Catalyzed C–H/N–O Bond Functionalization: Green Isoquinolone Syntheses in Water

Lutz Ackermann, Sabine Fenner · Organic Letters · 2011 · 364 citations · Full text

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Enantioselective Synthesis of 3,4-Dihydroisoquinolin-1(2<i>H</i>)-ones by Nickel-Catalyzed Denitrogenative Annulation of 1,2,3-Benzotriazin-4(3<i>H</i>)-ones with Allenes

Motoshi Yamauchi, Tomoya Miura, Masahiro Murakami · Journal of the American Chemical Society · 2009 · 159 citations

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Regioselective, palladium-catalyzed hetero- and carboannulation of 1,2-dienes using functionally substituted aryl halides

Richard C. Larock, Norman Berrios-Pena, Colleen A. Fried · The Journal of Organic Chemistry · 1991 · 155 citations

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