Lewis Acid Catalyzed Asymmetric Cycloadditions of Nitrones: α′‐Hydroxy Enones as Efficient Reaction Partners

Abstract

A fine pair: Excellent levels of regio-, endo/exo-, diastereo-, and/or enantioselectivity are attained in the Cu-catalyzed cycloaddition of nitrones with α′-hydroxy enones (see scheme). The resulting adducts can be further elaborated to the corresponding isoxazolidines bearing aldehyde, ketone, and carboxylic acid functions.