Protein and Peptide Letters · 2007 · 40 citations · 0 references
MedicineOphthalmologyPharmacologyAgingOcular DiseaseOcular PharmacologyAngiogenesisAntioxidant DefenseEndothelial ActivationEndothelial DysfunctionReactive Oxygen SpeciesRetinal Pigment EpitheliumAdvanced Glycation End ProductsAtherosclerosis Molecular MechanismsEndothelial Nitric Oxide Synthase DysfunctionNitric OxideNitric Oxide Synthase RegulationPigment Epithelium-derived FactorRetinal Angiogenesis InhibitionVascular Endothelial Dysfunction
PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis. Keywords: AGEs, eNOS, oxidative stress, PEDF, peroxynitrite