Stimulation of T Lymphocytes by Autologous non‐T Lymphoid Cells. Participation of HLA‐D?

Abstract

Non-T lymphoid cells were found to be able to stimulate autologous T cells in vitro. This "autologous" response was shown to be about 20% of the response to allogeneic unfractionated lymphocytes. The ability to induce autostimulation appeared to be a property of the Ig-positive lymphocyte fraction. Blocking experiments with allosera recognizing HLA-D-associated determinants suggested that the HLA-D determinants present on the stimulating cells might be involved in the stimulation of autologous T cells.