Archives of Internal Medicine · 1908 · 103 citations · 0 references
Veterinary MedicineInfectious DiseasesPathologyHistopathologyParasitologyProtozoologyParasitic Disease PathogenesisParasitic DiseasesParasitic InfectionsParasitic PathogenesisParasitic PathologyParasitic ZoonosesHistopathology Of ParasitesHistopathology Of Parasitic InfectionsHistoplasmosis LesionsParasitic Disease HistopathologyParasitic Disease PathologyParasitic InfestationsParasitic LesionsParasitic Pathology Diagnosis
<h3>INTRODUCTION.</h3> Histoplasmosis<sup>1</sup>is a term applied to a fatal infection by a protozoon,<i>Histoplasma capsulatum</i>, which has been encountered three times during the past two and one-half years in Ancon Hospital, Canal Zone, Panama. Clinically and pathologically the disease is suggestive of kala-azar,<sup>2</sup>a disease of India, characterized by irregular fever, emaciation and splenomegaly and by the presence of the Leishman-Donovan body in the tissues. The micro-organism responsible for the Isthmian infection is different from the Leishman-Donovan body, sufficiently so to warrant its being placed in a different order. The condition was not discovered until the autopsies, and chiefly on that account cultural experiments were unsuccessful and clinical data meager. <h3>HISTORICAL SKETCH.</h3> Cunningham<sup>3</sup>published in 1885 an account of bodies found in the tissue obtained from a Delhi boil. Cunningham's technic was crude and the bodies measured 8.8 to 12.6 microns—altogether too large to be the bodies