Structure and Unique Interactions with DNA of a Cationic <i>Trans</i>‐Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine Ligand

Abstract

Circumventing cisplatin resistance: The trans-[PtCl2(NH3)(pip-pip)]+ ion (see structure; red Pt, blue N, green Cl, gray C) is a cytotoxic compound with a cationic piperidinopiperidine ligand. The piperidine ring that is removed from the PtII center is fluxional and acts as a hydrogen-bond donor. The complex binds calf thymus DNA directly and rapidly (t1/2=11 min) without prior hydrolysis and circumvents cisplatin resistance in ovarian cancer cells.