Structure and Unique Interactions with DNA of a Cationic <i>Trans</i>‐Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine Ligand

Abstract

Circumventing cisplatin resistance: The trans-[PtCl2(NH3)(pip-pip)]+ ion (see structure; red Pt, blue N, green Cl, gray C) is a cytotoxic compound with a cationic piperidinopiperidine ligand. The piperidine ring that is removed from the PtII center is fluxional and acts as a hydrogen-bond donor. The complex binds calf thymus DNA directly and rapidly (t1/2=11 min) without prior hydrolysis and circumvents cisplatin resistance in ovarian cancer cells. Supporting information for this article (NMR spectra of 1) is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462389_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.