Concepedia

Novel Tight-Binding Inhibitory Factor-κB Kinase (IKK-2) Inhibitors Demonstrate Target-Specific Anti-Inflammatory Activities in Cellular Assays and following Oral and Local Delivery in an in Vivo Model of Airway Inflammation

Cynthia D. Sommers, Janice Thompson, Julia A. Guzova, Sheri L. Bonar, Randall K. Rader, Sumathy Mathialagan, Neetu Venkatraman, Vicky Walker Holway, Larry E. Kahn, George Hu,

Journal of Pharmacology and Experimental Therapeutics · 2009 · 33 citations · 31 references

DOI

Concepts

References

31

Cigarette smoke induces proinflammatory cytokine release by activation of NF-κB and posttranslational modifications of histone deacetylase in macrophages

Se‐Ran Yang, Asiya Seema Chida, Mark R. Bauter et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2006 · 495 citations

, , +17

Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages

Kazuhiro Ito, Shuang Fang Lim, Gaetano Caramori et al. · The FASEB Journal · 2001 · 453 citations

, , +17

Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD

Antonino Di Stefano, Gaetano Caramori, Thomas W. Oates et al. · European Respiratory Journal · 2002 · 430 citations · Full text

, , +17

Activation and Localization of Transcription Factor, Nuclear Factor- κ B, in Asthma

Lorraine Hart, VIJAYA L. KRISHNAN, Ian M. Adcock et al. · American Journal of Respiratory and Critical Care Medicine · 1998 · 423 citations

, , +17

Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease

Jean Bousquet, Pascal Chanez, J Simony-Lafontaine et al. · Journal of Allergy and Clinical Immunology · 1993 · 405 citations

, , +16