Non‐surgical periodontal therapy with adjunctive topical doxycycline: a double‐blind randomized controlled multicenter study

Abstract

Adjunctive topical subgingival application of a biodegradable 15% doxycycline gel was safe and provided more favorable RAL-V gain and PPD reduction than SRP alone and VEH. Thus, by use of topical doxycycline the threshold for surgical periodontal therapy might be moved toward deeper pockets.