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A Highly Efficient Palladium‐Catalyzed One‐Pot Synthesis of Unsymmetrical Aryl Alkyl Thioethers under Mild Conditions in Water
48
Citations
45
References
2012
Year
Room TemperatureChemical EngineeringCross-coupling ReactionEngineeringNatural SciencesDiversity-oriented SynthesisMild ConditionsPolyoxyethanyl α‐Tocopheryl SebacateAlkyl BromidesOrganic ChemistryOrganometallic CatalysisCatalysisChemistryAsymmetric CatalysisSynthetic ChemistryEnantioselective Synthesis
Abstract A palladium‐catalyzed, one‐pot synthesis of unsymmetrical aryl alkyl thioethers involving aryl halides (aryl bromides and chlorides), thiourea and alkyl bromides has been realized under mild conditions (room temperature to 50 °C) in water with polyoxyethanyl α‐tocopheryl sebacate (PTS) as amphiphile. The PTS/water could be recycled in up to eight runs without an obvious change in its activity.
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