Effects of the Long-Acting Human Glucagon-Like Peptide-1 Analog Liraglutide on β-Cell Function in Normal Living Conditions

Abstract

iraglutide is a long-acting glucagonlike peptide (GLP)-1 analog, which exerts its glucose-lowering action through multiple mechanisms (1). One important feature of liraglutide is its ability to enhance -cell function. The effects on -cell function have been demonstrated using standardized -cell function tests based on intravenous glucose administration (2-4). However, these studies may not reflect the modes of action of liraglutide during normal living. To assess the effects of liraglutide on -cell function in normal living, we have used a validated -cell model to analyze 24-h triple-meal experiments.