Bicyclic Peroxides and Perorthoesters with 1,2,4‐Trioxane Structures

Abstract

Resistance effects to the antimalarial agent artemisinin and its derivatives spurs on the search for new compounds with related cyclic peroxide structures. A flexible route to new bicyclic peroxides and perorthoesters is provided by a sequence of 1O2 ene reaction and subsequent Lewis acid catalyzed peroxyacetalization. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701397_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.