Concepedia

<i>Clostridium perfringens</i> Enterotoxin Damages the Human Intestine In Vitro

Mariano E. Fernández-Miyakawa, Virginia Pistone Creydt, Francisco A. Uzal, Bruce A. McClane, Cristina Ibarra

Infection and Immunity · 2005 · 72 citations · 24 references

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Concepts

Abstract

In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption. CPE also binds to the human colon in vitro but causes only slight morphological and transport changes that are not statistically significant.

References

24

<i>Clostridium perfringens</i> enterotoxin binds to the second extracellular loop of claudin‐3, a tight junction integral membrane protein

Kohji Fujita, Jun Katahira, Yasuhiko Horiguchi et al. · FEBS Letters · 2000 · 280 citations

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Clostridium perfringens Enterotoxin Utilizes Two Structurally Related Membrane Proteins as Functional Receptors in Vivo

Jun Katahira, Hiromu Sugiyama, Norimitsu Inoue et al. · Journal of Biological Chemistry · 1997 · 276 citations · Full text

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Inactivation of the gene (<i>cpe</i> ) encoding <i>Clostridium perfringens</i> enterotoxin eliminates the ability of two <i>cpe</i>‐positive <i>C. perfringens</i> type A human gastrointestinal disease isolates to affect rabbit ileal loops

Mahfuzur R. Sarker, Robert J. Carman, Bruce A. McClane · Molecular Microbiology · 1999 · 234 citations · Full text

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Fatal Necrotizing Colitis Following a Foodborne Outbreak of Enterotoxigenic Clostridium perfringens Type A Infection

J. Bos, Lauri Smithee, B.A. McClane et al. · Clinical Infectious Diseases · 2005 · 115 citations

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Death Pathways Activated in CaCo-2 Cells by <i>Clostridium perfringens</i> Enterotoxin

Ganes Chakrabarti, Xin Zhou, Bruce A. McClane · Infection and Immunity · 2003 · 109 citations · Full text

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