Angewandte Chemie International Edition · 2012 · 175 citations · 20 references
PharmacyPharmaceuticsPharmacologyCancer PharmacologyNanomaterialsNanotechnologyCancer NanomedicineCell-nanoparticle InteractionsNanomedicineNanoparticle CharacterizationNanoparticle StabilityNanoparticle SynthesisCancer NanotherapyNanoparticle CytotoxicityNanoparticle PharmacologyNanoparticle ToxicityNanoparticle-based ChemotherapyNanoparticle-delivered ProdrugsNanoparticle-induced CytotoxicityProdrug Nanoparticles
A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.
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