Suppression of <scp>B</scp> ‐cell activation and <scp>I</scp> g <scp>E</scp> , <scp>I</scp> g <scp>A</scp> , <scp>I</scp> g <scp>G</scp> 1 and <scp>I</scp> g <scp>G</scp> 4 production by mammalian telomeric oligonucleotides

Abstract

B cells require specific TLR stimulation, T-cell and plasmacytoid dendritic cell help for distinct activation and Ig production profiles. Host-derived telomeric ODN suppress B-cell activation and antibody production demonstrating a natural mechanism for the control of overexuberant B-cell activation, antibody production and generation of memory.